Ouabain mimics low temperature rescue of F508del-CFTR in cystic fibrosis epithelial cells

ABSTRACT Most cases of cystic fibrosis (CF) are caused by the deletion of a single phenylalanine residue at position 508 of the cystic fibrosis transmembrane conductance regulator (CFTR). The mutant F508del-CFTR is retained in the endoplasmic reticulum and degraded, but can be induced by low tempera...

Полное описание

Библиографические подробности

Главные авторы:	Donglei eZhang, Fabiana eCiciriello, Suzana eAnjos, Annamaria eCarissimo, Jie eLiao, Graeme eCarlile, Haouaria eBalghi, Renaud eRobert, Alberto eLuini, John eHanrahan, David eThomas
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2012-10-01
Серии:	Frontiers in Pharmacology
Предметы:	Cystic Fibrosis Ouabain Microarray trafficking CFTR hierarchical clustering
Online-ссылка:	http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00176/full
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!