Ouabain mimics low temperature rescue of F508del-CFTR in cystic fibrosis epithelial cells
ABSTRACT Most cases of cystic fibrosis (CF) are caused by the deletion of a single phenylalanine residue at position 508 of the cystic fibrosis transmembrane conductance regulator (CFTR). The mutant F508del-CFTR is retained in the endoplasmic reticulum and degraded, but can be induced by low tempera...
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| Principais autores: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Frontiers Media S.A.
2012-10-01
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| Serier: | Frontiers in Pharmacology |
| Fag: | |
| Online adgang: | http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00176/full |
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