Deubiquitinase YOD1 Inhibition Suppresses DEX‐ and Denervation‐Induced Muscle Atrophy Through MAFbx Destabilization

ABSTRACT Backgrounds Muscle atrophy, characterized by progressive loss of muscle mass and function, is driven by muscle‐specific E3 ligases MAFbx and MuRF1. While transcriptional regulation of E3 ligases is documented, the mechanism of their regulation by the ubiquitin–proteasome system remains uncl...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Jongbeom Chae, Seon Min Woo, Seung Un Seo, Simmyung Yook, Hyo Je Cho, Jung Yeol Lee, Kyoung jin Min, Junhyeon Park, Dongryeol Ryu, Taeg Kyu Kwon
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2026-06-01
coleção:	Journal of Cachexia, Sarcopenia and Muscle
Assuntos:	deubiquitinase MAFbx muscle atrophy ubiquitin proteasome system YOD1
Acesso em linha:	https://doi.org/10.1002/jcsm.70300
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!