Deubiquitinase YOD1 Inhibition Suppresses DEX‐ and Denervation‐Induced Muscle Atrophy Through MAFbx Destabilization
ABSTRACT Backgrounds Muscle atrophy, characterized by progressive loss of muscle mass and function, is driven by muscle‐specific E3 ligases MAFbx and MuRF1. While transcriptional regulation of E3 ligases is documented, the mechanism of their regulation by the ubiquitin–proteasome system remains uncl...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Wiley
2026-06-01
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| Col·lecció: | Journal of Cachexia, Sarcopenia and Muscle |
| Matèries: | |
| Accés en línia: | https://doi.org/10.1002/jcsm.70300 |
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