Rodent models in Down syndrome research: impact and future opportunities

Down syndrome is caused by trisomy of chromosome 21. To date, a multiplicity of mouse models with Down-syndrome-related features has been developed to understand this complex human chromosomal disorder. These mouse models have been important for determining genotype-phenotype relationships and ident...

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Podrobná bibliografie

Hlavní autoři:	Yann Herault, Jean M. Delabar, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz, Eugene Yu, Veronique Brault
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	The Company of Biologists 2017-10-01
Edice:	Disease Models & Mechanisms
Témata:	Down syndrome Mouse model Chromosome engineering Aneuploidy Dosage-senstive gene
On-line přístup:	http://dmm.biologists.org/content/10/10/1165
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