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Dissecting the contribution of human chromosome 21 syntenic regions to recognition memory processes in adult and aged mouse models of Down syndrome

BackgroundTrisomy of human chromosome 21 (Hsa21) results in a constellation of features known as Down syndrome (DS), the most common genetic form of intellectual disability. Hsa21 is orthologous to three regions in the mouse genome on mouse chromosome 16 (Mmu16), Mmu17 and Mmu10. We investigated gen...

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Main Authors: Tara Canonica, Emma J. Kidd, Dorota Gibbins, Eva Lana-Elola, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz, Mark Good
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2024-07-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
down syndrome
mouse models
recognition memory
object tasks
aging
hippocampus
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2024.1428146/full
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