Mutations of RagA GTPase in mTORC1 Pathway Are Associated with Autosomal Dominant Cataracts.

Cataracts are a significant public health problem with no proven methods for prevention. Discovery of novel disease mechanisms to delineate new therapeutic targets is of importance in cataract prevention and therapy. Herein, we report that mutations in the RagA GTPase (RRAGA), a key regulator of the...

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Autors principals:	Jian-Huan Chen, Chukai Huang, Bining Zhang, Shengjie Yin, Jiajian Liang, Ciyan Xu, Yuqiang Huang, Ling-Ping Cen, Tsz-Kin Ng, Ce Zheng, Shaobin Zhang, Haoyu Chen, Chi-Pui Pang, Mingzhi Zhang
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2016-06-01
Col·lecció:	PLoS Genetics
Accés en línia:	http://europepmc.org/articles/PMC4905677?pdf=render
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