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Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes

Abstract The mechanistic target of rapamycin complex 1 (mTORC1) is an essential regulator of cell growth and metabolism through the modulation of protein and lipid synthesis, lysosome biogenesis, and autophagy. The activity of mTORC1 is dynamically regulated by several environmental cues, including...

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Principais autores: Terunao Takahara, Yuna Amemiya, Risa Sugiyama, Masatoshi Maki, Hideki Shibata
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2020-08-01
Series:Journal of Biomedical Science
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Acceso en liña:http://link.springer.com/article/10.1186/s12929-020-00679-2
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