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Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes

Abstract The mechanistic target of rapamycin complex 1 (mTORC1) is an essential regulator of cell growth and metabolism through the modulation of protein and lipid synthesis, lysosome biogenesis, and autophagy. The activity of mTORC1 is dynamically regulated by several environmental cues, including...

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Autori principali: Terunao Takahara, Yuna Amemiya, Risa Sugiyama, Masatoshi Maki, Hideki Shibata
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2020-08-01
Serie:Journal of Biomedical Science
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Accesso online:http://link.springer.com/article/10.1186/s12929-020-00679-2
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