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In-host modeling of Tfh–Tfr–fCD8+ T cell dynamics on HIV reservoir persistence

HIV persistence within germinal centers is driven by complex interactions among T follicular helper (Tfh), T follicular regulatory (Tfr), and follicular CD8+ (fCD8+) T cells. Yet, the mechanisms sustaining the viral reservoir remain poorly understood. We developed a mechanistic within-host mathemati...

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Principais autores: Faraimunashe Chirove, Koffi Messan Agbavon
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-07-01
Serier:Frontiers in Applied Mathematics and Statistics
Fag:
dynamical systems
fCD8(+) T cells
HIV reservoir persistence
nonstandard finite difference (NSFD)
stability analysis
Tfh cells
Online adgang:https://www.frontiersin.org/articles/10.3389/fams.2026.1875113/full
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