In-host modeling of Tfh–Tfr–fCD8+ T cell dynamics on HIV reservoir persistence

HIV persistence within germinal centers is driven by complex interactions among T follicular helper (Tfh), T follicular regulatory (Tfr), and follicular CD8+ (fCD8+) T cells. Yet, the mechanisms sustaining the viral reservoir remain poorly understood. We developed a mechanistic within-host mathemati...

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Autors principals:	Faraimunashe Chirove, Koffi Messan Agbavon
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-07-01
Col·lecció:	Frontiers in Applied Mathematics and Statistics
Matèries:	dynamical systems fCD8(+) T cells HIV reservoir persistence nonstandard finite difference (NSFD) stability analysis Tfh cells
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fams.2026.1875113/full
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