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Priming as a strategy to overcome detrimental pH effects on cells for intervertebral disc regeneration

Disc disease is characterised by degeneration of the nucleus pulposus (NP), the central gelatinous tissue of the intervertebral disc (IVD). As degeneration progresses, the microenvironment of the IVD becomes more hostile (i.e. decrease in oxygen, glucose and pH), providing a significant challenge fo...

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Principais autores: J Gansau, CT Buckley
Format: Artigo
Sprog:Inglês
Udgivet: Forum Multimedia Publishing LLC 2021-02-01
Serier:European Cells & Materials
Fag:
acid-sensing ion channel
articular chondrocytes
bone-marrow-derived stem cells
hydrogel
metabolism
nucleus pulposus
pre-culture
transforming growth factor β3
Online adgang:https://www.ecmjournal.org/papers/vol041/pdf/v041a11.pdf
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