Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

Abstract Background Converging evidence suggests a role for microglia-mediated neuroinflammation in Parkinson’s disease (PD). Animal models of PD can serve as a platform to investigate the role of neuroinflammation in degeneration in PD. However, due to features of the previously available PD models...

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Principais autores:	Megan F. Duffy, Timothy J. Collier, Joseph R. Patterson, Christopher J. Kemp, Kelvin C. Luk, Malú G. Tansey, Katrina L. Paumier, Nicholas M. Kanaan, D. Luke Fischer, Nicole K. Polinski, Olivia L. Barth, Jacob W. Howe, Nishant N. Vaikath, Nour K. Majbour, Omar M. A. El-Agnaf, Caryl E. Sortwell
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2018-05-01
Series:	Journal of Neuroinflammation
Assuntos:	Neuroinflammation Parkinson’s disease Animal models Synucleinopathy Microglia Major-histocompatibility complex-II
Acceso en liña:	http://link.springer.com/article/10.1186/s12974-018-1171-z
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