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Ser129 phosphorylation of endogenous α-synuclein induced by overexpression of polo-like kinases 2 and 3 in nigral dopamine neurons is not detrimental to their survival and function

Phosphorylation of the α-synuclein (α-syn) protein at Ser129 [P(S129)-α-syn] was found to be the most abundant form in intracellular inclusions in brains from Parkinson's disease (PD) patients. This finding suggests that P(S129)-α-syn plays a central role in the pathogenesis of PD. However, it is at...

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Auteurs principaux: Kerstin Buck, Natalie Landeck, Ayse Ulusoy, Nour K. Majbour, Omar M.A. El-Agnaf, Deniz Kirik
Format: Artigo
Langue:Inglês
Publié: Elsevier 2015-06-01
Collection:Neurobiology of Disease
Sujets:
α-Synuclein
Phosphorylation
Polo-like kinase
Adeno-associated vector
Parkinson's disease
Accès en ligne:http://www.sciencedirect.com/science/article/pii/S0969996115000704
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