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A phase I study of dasatinib with concurrent chemoradiation for stage III non small cell lung cancer (NSCLC)

Objectives: Src family kinases (SFKs) are expressed in NSCLC and may be involved in tumor growth and metastases. Inhibition of SFK may also enhance radiation. The purpose of this study was to evaluate if a maximum dose of 100 mg of dasatinib could be safely administered with concurrent chemoradiati...

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Principais autores: Howard eSafran, Thomas eDiPetrillo, Humera eKhurshid, Thomas eNg, Kalyan eMantripragada, Ariel eBirnbaum, David eBerz, Kathy eRadie-Keane, Kimberly ePerez, Maria eConstantinou, Denise eLuppe, Andrew eSchumacher, Kara eLeonard
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2012-05-01
Serier:Frontiers in Oncology
Fag:
Radiation
lung cancer
src
Dasatinib
Online adgang:http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00056/full
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