Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling

Summary: Hepatocellular carcinoma (HCC) remains one of the deadliest malignancies worldwide. One major obstacle to treatment is a lack of effective molecular-targeted therapies. In this study, we find that EphA2 expression and signaling are enriched in human HCC and associated with poor prognosis. L...

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Autori principali:	Hao Wang, Wei Hou, Aldeb Perera, Carlee Bettler, Jordan R. Beach, Xianzhong Ding, Jun Li, Mitchell F. Denning, Asha Dhanarajan, Scott J. Cotler, Cara Joyce, Jun Yin, Fowsiyo Ahmed, Lewis R. Roberts, Wei Qiu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2021-02-01
Serie:	Cell Reports
Soggetti:	EphA2 HCC AKT STAT3 JAK1
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2211124721000784
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