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Acylhydrazone derivatives of barbituric acid: Synthesis, in vitro α-amylase inhibition, molecular docking, ADMET and DFT analysis

In this study, a new series of acylhydrazones of barbituric acid were successfully synthesized and characterized through mass, 1H and 13C NMR spectroscopy. The compounds (4a-f) were assessed for their in vitro α-amylase inhibitory activity, showing potent inhibition with IC50 values ranging from 2.4...

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Autori principali: Aneela Jabbar, Ahmed A. Elhenawy, Muhammad Ayaz, Aftab Alam, Abbas Khan, Syed Adnan Ali Shah, Imen Zghab, Khair Zaman
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2025-09-01
Serie:Results in Chemistry
Soggetti:
Barbituric acid
Acylhydrazones
Α-Amylase inhibitors
Molecular docking
ADMET
DFT calculations
Accesso online:http://www.sciencedirect.com/science/article/pii/S2211715625006344
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