Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

Abstract Inflammatory bowel diseases (IBD) affect over 6 million people globally and current treatments achieve only 10‐20% rates of durable disease remission. Bacterial extracellular vesicles (BEVs) from probiotic lactic acid bacteria (LAB) are a promising novel therapeutic with mechanisms holding...

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主要な著者:	Nicholas H Pirolli, Daniel Levy, Alyssa Schledwitz, Natalia Sampaio Moura, Mitali Sarkar, Talia J. Solomon, Emily H. Powsner, Raith Nowak, Zuzanna Mamczarz, Christopher J. Bridgeman, Sulayman Khan, Andrew Hui, Nidhi Anne, Laura Reus, William E. Bentley, Jean‐Pierre Raufman, Steven M. Jay
フォーマット:	Artigo
言語:	Inglês
出版事項:	Wiley 2026-02-01
シリーズ:	Advanced Science
主題:	bacterial membrane vesicles colitis extracellular vesicles IBD lactic acid bacteria
オンライン･アクセス:	https://doi.org/10.1002/advs.202512679
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