Distinct cerebrospinal fluid proteomic signatures define clinicopathological subtypes of sporadic Creutzfeldt-Jakob disease and predict patient survival

Abstract Sporadic Creutzfeldt-Jakob disease (sCJD) is a highly heterogeneous neurodegenerative disorder encompassing six major histopathological and molecular subtypes, showing diverse clinical features and prognosis. Currently, no accurate biomarkers are available for the antemortem differentiation...

Descrición completa

Detalles Bibliográficos

Principais autores:	Giuseppe Mario Bentivenga, Angela Mammana, Dea Gogishvili, Simone Baiardi, Erica Vittoriosi, Andrea Mastrangelo, Agustina Ranieri, Isabel M. Houtkamp, Kathrin Brockmann, Sanne Abeln, Sabina Capellari, Piero Parchi
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2025-12-01
Series:	Acta Neuropathologica Communications
Assuntos:	Prion Creutzfeldt–Jakob disease Biomarker Cerebrospinal fluid Proteomic Proximity extension assay
Acceso en liña:	https://doi.org/10.1186/s40478-025-02168-9
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!