TRACKING HER2 TRAFFICKING AND ORGANELLE CROSSTALK IN TRASTUZUMAB-DERUXTECAN–TREATED BREAST CANCER CELLS USING MULTIMODAL IMAGING

Trastuzumab-deruxtecan (T-DXd) is a clinically effective antibody–drug conjugate (ADC) for HER2+ and HER2-low breast cancers, yet its intracellular mechanisms remain elusive. We used a multimodal imaging approach including confocal, immuno-EM, and biochemical assays to investigate T-DXd dynamics in...

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Médium:	Artigo
Jazyk:	Inglês
Vydáno:	PAGEPress Publications 2025-08-01
Edice:	European Journal of Histochemistry
Témata:	WORKSHOP: NEW HORIZONS IN FLOW CYTOMETRY: ADVANCES IN ANALYSES AND CHARACTERIZATION OF EXTRACELLULAR VESICLES
On-line přístup:	https://www.ejh.it/ejh/article/view/4305
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