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Activation of gut FXR improves the metabolism of bile acids, intestinal barrier, and microbiota under cholestatic condition caused by GCDCA in mice

ABSTRACT Abnormal bile acid (BA) metabolism is involved in liver fibrosis. In a previous study, we discovered that the hydrophobic BA glycochenodeoxycholate (GCDCA) induced liver fibrosis and that GW4064, an agonist of farnesoid X receptor (FXR), alleviated liver fibrosis caused by GCDCA. However, t...

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Principais autores: Xing-Ming Xie, Bang-Yan Zhang, Shu Feng, Zi-Jun Fan, Guo-Ying Wang
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2025-04-01
Serier:Microbiology Spectrum
Fag:
cholestasis
glycochenodeoxycholate
GW4064
bile acid
gut microbiota
Online adgang:https://journals.asm.org/doi/10.1128/spectrum.03150-24
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