Targeting the microglial phosphatidylethanolamine synthesis pathway promotes GABARAP-associated phagocytosis and Aβ clearance in Alzheimer’s disease

Abstract Alzheimer’s disease (AD) is a major cause of dementia and a prevalent age-related neurodegenerative disorder characterized by progressive cognitive impairment and memory loss. Although metabolic activation or dysfunction of microglia is implicated in AD pathogenesis, the phospholipid metabo...

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Autori principali:	Seung Jae Hyeon, Seung Chan Kim, Jiyeon Chu, Yeonseo Kim, Chaebin Kim, Uiyeol Park, Zahid Tufail, Phuong Thi Thanh Nguyen, Ahreum Eom, Sojung Kim, Yeyun Kim, Eunkyung Lee, Suhyun Kim, Seung Eun Lee, Jiwan Woo, Jin-A Lee, Kyung Eun Lee, Thor D. Stein, Hyunbeom Lee, Junghee Lee, Hoon Ryu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2026-07-01
Serie:	Signal Transduction and Targeted Therapy
Accesso online:	https://doi.org/10.1038/s41392-026-02789-z
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