Astrocytic noncanonical WNT5B signaling modulates extracellular matrix remodeling and neuropathology in Huntington’s disease

Abstract Huntington’s disease (HD) is a fatal neurodegenerative disorder characterized by a triad of behavioral symptoms: involuntary movement, emotional change, and cognitive dysfunction. Although alterations in WNT signaling have been reported in HD, its precise role in pathogenesis remains unclea...

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Egile Nagusiak:	Phuong Thi Thanh Nguyen, Ali Yousefian-Jazi, Seung Jae Hyeon, Soomin Lee, Seung Chan Kim, Uiyeol Park, Yeeun Jeong, Sojung Kim, Suhyun Kim, Yeyun Kim, Hannah L. Ryu, Kyung Eun Lee, Thor D. Stein, Richard H. Myers, Eun Mi Hwang, Junghee Lee, Hoon Ryu
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Nature Publishing Group 2026-01-01
Saila:	Signal Transduction and Targeted Therapy
Sarrera elektronikoa:	https://doi.org/10.1038/s41392-025-02545-9
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