An integrated model of acinar to ductal metaplasia-related N7-methyladenosine regulators predicts prognosis and immunotherapy in pancreatic carcinoma based on digital spatial profiling

Acinar-to-ductal metaplasia (ADM) is a recently recognized, yet less well-studied, precursor lesion of pancreatic ductal adenocarcinoma (PDAC) developed in the setting of chronic pancreatitis. Through digital spatial mRNA profiling, we compared ADM and adjacent PDAC tissues from patient samples to u...

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Autori principali:	Hao Yang, Julia Messina-Pacheco, Andrea Liliam Gomez Corredor, Alex Gregorieff, Jun-li Liu, Ali Nehme, Hamed S. Najafabadi, Yasser Riazalhosseini, Bo Gao, Zu-hua Gao
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2022-07-01
Serie:	Frontiers in Immunology
Soggetti:	acinar to ductal metaplasia N7-methyladenosine pancreatic carcinoma prognosis immunotherapy digital spatial profiling
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.961457/full
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