Stepwise increase of fidaxomicin in an engineered heterologous host Streptomyces albus through multi-level metabolic engineering
The anti-Clostridium difficile infection (CDI) drug fidaxomicin is a natural polyketide metabolite mainly produced by Micromonosporaceae, such as Actinoplanes deccanensis, Dactylosporangium aurantiacum, and Micromonospora echinospora. In the present study, we employed a stepwise strategy by combinin...
Furkejuvvon:
| Váldodahkkit: | , , , , , , |
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| Materiálatiipa: | Artigo |
| Giella: | Inglês |
| Almmustuhtton: |
KeAi Communications Co., Ltd.
2024-12-01
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| Ráidu: | Synthetic and Systems Biotechnology |
| Fáttát: | |
| Liŋkkat: | http://www.sciencedirect.com/science/article/pii/S2405805X24000930 |
| Fáddágilkorat: |
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