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Impairment of TrkB-PSD-95 signaling in Angelman syndrome.

Angelman syndrome (AS) is a neurodevelopment disorder characterized by severe cognitive impairment and a high rate of autism. AS is caused by disrupted neuronal expression of the maternally inherited Ube3A ubiquitin protein ligase, required for the proteasomal degradation of proteins implicated in s...

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Autors principals: Cong Cao, Mengia S Rioult-Pedotti, Paolo Migani, Crystal J Yu, Rakesh Tiwari, Keykavous Parang, Mark R Spaller, Dennis J Goebel, John Marshall
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2013-01-01
Col·lecció:PLoS Biology
Accés en línia:http://europepmc.org/articles/PMC3570550?pdf=render
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