Colony-Stimulating Factor-1 Receptor Inhibition Transiently Attenuated the Peripheral Immune Response to Experimental Traumatic Brain Injury

To investigate microglial mechanisms in central and peripheral inflammation after experimental traumatic brain injury (TBI), we inhibited the colony-stimulating factor-1 receptor (CSF-1R) with PLX5622 (PLX). We hypothesized that microglia depletion would attenuate central inflammation acutely with n...

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Bibliografski detalji

Glavni autori:	Katherine R. Giordano, Maha Saber, Tabitha R.F. Green, Luisa M. Rojas-Valencia, J. Bryce Ortiz, Sean M. Murphy, Jonathan Lifshitz, Rachel K. Rowe
Format:	Artigo
Jezik:	Inglês
Izdano:	SAGE Publishing 2023-04-01
Serija:	Neurotrauma Reports
Teme:	concussion inflammation microglia peripheral immune response PLX
Online pristup:	https://www.liebertpub.com/doi/full/10.1089/NEUR.2022.0092
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