Optimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B virus infection

Abstract This study aimed to develop a pan-genotypic and multifunctional small interfering RNA (siRNA) against hepatitis B virus (HBV) with an efficient delivery system for treating chronic hepatitis B (CHB), and explore combined RNA interference (RNAi) and immune modulatory modalities for better vi...

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Principais autores:	Wenjing Zai, Min Yang, Kuan Jiang, Juan Guan, Huijing Wang, Kongying Hu, Chao Huang, Jieliang Chen, Wei Fu, Changyou Zhan, Zhenghong Yuan
格式:	Artigo
語言:	Inglês
出版:	Nature Publishing Group 2024-06-01
叢編:	Signal Transduction and Targeted Therapy
在線閱讀:	https://doi.org/10.1038/s41392-024-01871-8
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