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Calpain-6 deficiency promotes skeletal muscle development and regeneration.

Calpains are Ca(2+)-dependent modulator Cys proteases that have a variety of functions in almost all eukaryotes. There are more than 10 well-conserved mammalian calpains, among which eutherian calpain-6 (CAPN6) is unique in that it has amino acid substitutions at the active-site Cys residue (to Lys...

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Principais autores: Kazuo Tonami, Shoji Hata, Koichi Ojima, Yasuko Ono, Yukiko Kurihara, Tomokazu Amano, Takahiro Sato, Yumiko Kawamura, Hiroki Kurihara, Hiroyuki Sorimachi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2013-01-01
Serier:PLoS Genetics
Online adgang:http://europepmc.org/articles/PMC3731218?pdf=render
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