Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition

Abstract Background Delayed healing of diabetic cutaneous wounds is one of the most common complications of type 2 diabetes mellitus (T2DM), which can bring great distress to patients. In diabetic patients, macrophages accumulate around skin wounds and produce NLRP3 (NOD-, LRR-, and pyrin domain-con...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Yiming Wang, Lin Jing, Xiao Lei, Zhen Ma, Bei Li, Yuanyuan Shi, Wuyang Zhang, Yuan Li, Hongzhi Zhou, Kaijin Hu, Yang Xue, Yan Jin
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2023-09-01
Schriftenreihe:	Stem Cell Research & Therapy
Schlagworte:	Diabetic cutaneous wound Apoptotic extracellular vesicles Pyroptosis Oxidative stress Cell death regulation
Online-Zugang:	https://doi.org/10.1186/s13287-023-03490-6
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!