Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition

Abstract Background Delayed healing of diabetic cutaneous wounds is one of the most common complications of type 2 diabetes mellitus (T2DM), which can bring great distress to patients. In diabetic patients, macrophages accumulate around skin wounds and produce NLRP3 (NOD-, LRR-, and pyrin domain-con...

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Autori principali:	Yiming Wang, Lin Jing, Xiao Lei, Zhen Ma, Bei Li, Yuanyuan Shi, Wuyang Zhang, Yuan Li, Hongzhi Zhou, Kaijin Hu, Yang Xue, Yan Jin
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2023-09-01
Serie:	Stem Cell Research & Therapy
Soggetti:	Diabetic cutaneous wound Apoptotic extracellular vesicles Pyroptosis Oxidative stress Cell death regulation
Accesso online:	https://doi.org/10.1186/s13287-023-03490-6
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