Ferulic acid alleviates lipotoxicity-induced hepatocellular death through the SIRT1-regulated autophagy pathway and independently of AMPK and Akt in AML-12 hepatocytes

Abstract Background Lipotoxicity-induced cell death plays a detrimental role in the pathogenesis of metabolic diseases. Ferulic acid, widespread in plant-based food, is a radical scavenger with multiple bioactivities. However, the benefits of ferulic acid against hepatic lipotoxicity are largely unc...

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Detalhes bibliográficos

Principais autores:	Tiantian Xu, Qing Song, Li Zhou, Wenwen Yang, Xiangyao Wu, Qianyu Qian, Hui Chai, Qiang Han, Hongzhi Pan, Xiaobing Dou, Songtao Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2021-01-01
coleção:	Nutrition & Metabolism
Assuntos:	Ferulic acid SIRT1 Autophagy Lipotoxicity Metabolic diseases
Acesso em linha:	https://doi.org/10.1186/s12986-021-00540-9
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