Structural basis of TRPV1 inhibition by SAF312 and cholesterol
Abstract Transient Receptor Potential Vanilloid 1 (TRPV1) plays a central role in pain sensation and is thus an attractive pharmacological drug target. SAF312 is a potent, selective, and non-competitive antagonist of TRPV1 and shows promising potential in treating ocular surface pain. However, the p...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2024-08-01
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| Serie: | Nature Communications |
| Accesso online: | https://doi.org/10.1038/s41467-024-51085-3 |
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