Protocol to perform fragment screening using NMR spectroscopy

Summary: Fragment-based drug design plays an important role in drug discovery. Protein-observed NMR experiments with isotopically labeled samples are used to probe target-ligand interactions and map the ligand-binding sites. Here, we present a protocol to perform fragment screening using NMR spectro...

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Autors principals:	Qiwei Huang, CongBao Kang
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2024-09-01
Col·lecció:	STAR Protocols
Matèries:	high-throughput screening protein expression and purification NMR
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S266616672400443X
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