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Activation of sarcolipin expression and altered calcium cycling in LMNA cardiomyopathy

Cardiomyopathy caused by A-type lamins gene (LMNA) mutations (LMNA cardiomyopathy) is associated with dysfunction of the heart, often leading to heart failure. LMNA cardiomyopathy is highly penetrant with bad prognosis with no specific therapy available. Searching for alternative ways to halt the pr...

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Main Authors: Blanca Morales Rodriguez, Alejandro Domínguez-Rodríguez, Jean-Pierre Benitah, Florence Lefebvre, Thibaut Marais, Nathalie Mougenot, Philippe Beauverger, Gisèle Bonne, Véronique Briand, Ana-María Gómez, Antoine Muchir
Format: Artigo
Language:Inglês
Published: Elsevier 2020-07-01
Series:Biochemistry and Biophysics Reports
Subjects:
Sarcolipin
Calcium handling
Nuclear envelope
LMNA
Dilated cardiomyopathy
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580820300765
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