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Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development

Regulatory T (Treg) cells are essential for the maintenance of immunological tolerance, yet the molecular components required for their maintenance and effector functions remain incompletely defined. Inactivation of VPS34 in Treg cells led to an early, lethal phenotype, with massive effector T cell...

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Principais autores: Christina J. F. Courreges, Elizabeth C. M. Davenport, Benoit Bilanges, Elena Rebollo-Gomez, Jens Hukelmann, Priya Schoenfelder, James R. Edgar, David Sansom, Cheryl L. Scudamore, Rahul Roychoudhuri, Oliver A. Garden, Bart Vanhaesebroeck, Klaus Okkenhaug
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-11-01
Serier:Frontiers in Immunology
Fag:
PI3K
Treg
VPS34
autophagy
endocytosis
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1374621/full
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