Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development

Regulatory T (Treg) cells are essential for the maintenance of immunological tolerance, yet the molecular components required for their maintenance and effector functions remain incompletely defined. Inactivation of VPS34 in Treg cells led to an early, lethal phenotype, with massive effector T cell...

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Bibliografski detalji

Glavni autori:	Christina J. F. Courreges, Elizabeth C. M. Davenport, Benoit Bilanges, Elena Rebollo-Gomez, Jens Hukelmann, Priya Schoenfelder, James R. Edgar, David Sansom, Cheryl L. Scudamore, Rahul Roychoudhuri, Oliver A. Garden, Bart Vanhaesebroeck, Klaus Okkenhaug
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2024-11-01
Serija:	Frontiers in Immunology
Teme:	PI3K Treg VPS34 autophagy endocytosis
Online pristup:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1374621/full
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