Co-stimulation of CD28/CD40 signaling molecule potentiates CAR-T cell efficacy and stemness

CD19 chimeric antigen receptor T (CD19CAR-T) cells have achieved promising outcomes in relapsed/refractory B cell malignancies. However, recurrences occur due to the loss of CAR-T cell persistence. We developed dual T/B cell co-stimulatory molecules (CD28 and CD40) in CAR-T cells to enhance intense...

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Autors principals:	Wannakorn Khopanlert, Pongsakorn Choochuen, Kajornkiat Maneechai, Nawaphat Jangphattananont, Socheatraksmey Ung, Shingo Okuno, Peter Steinberger, Judith Leitner, Surasak Sangkhathat, Pongtep Viboonjuntra, Seitaro Terakura, Jakrawadee Julamanee
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2024-09-01
Col·lecció:	Molecular Therapy: Oncology
Matèries:	MT: Regular Issue CD28/CD40 co-stimulatory domain CD19 CD37 CAR-T cell
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2950329924000791
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