Evaluating transportability of in vitro cellular models to in vivo human phenotypes using gene perturbation data

Abstract Gene perturbation screens (e.g. CRISPR-Cas9) assess the impact of gene disruption on in-vitro cellular phenotypes (e.g., proliferation, anti-viral response). In-vitro experiments can be useful models for in-vivo (organismal) phenotypes (e.g., immune cell anti-viral response and infectious d...

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Autors principals:	Laurence J. Howe, Yurii S. Aulchenko, George Davey Smith, Neil M. Davies, Jorge Esparza-Gordillo, Toby Johnson, Jimmy Z. Liu, Tom G. Richardson, Philippe Sanseau, Robert A. Scott, Daniel D. Seaton, Ashwini Sharma, Adrian Cortes
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-12-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-025-67199-1
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