COLEC12 tumor-associated macrophages orchestrate lenvatinib resistance and cancer stemness in hepatocellular carcinoma via paracrine NRG1-HER2/HER3 signaling

Background/Aims Lenvatinib resistance remains a critical barrier in advanced hepatocellular carcinoma (HCC) therapy. However, the underlying mechanisms and strategies for reversing resistance remain incompletely understood. Methods Integrated transcriptomics of lenvatinib-resistant patient tumors an...

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Detalhes bibliográficos

Principais autores:	Jianxing Zhang, Liang Qiao, Zongfeng Wu, Dinglan Zuo, Shanshan Huang, Shaoru Liu, Zhenkun Huang, Yi Zeng, Yu Li, Yichuan Yuan, Chenwei Wang, Wei He, Jiliang Qiu, Yunfei Yuan, Yi Niu, Binkui Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Korean Association for the Study of the Liver 2026-04-01
coleção:	Clinical and Molecular Hepatology
Assuntos:	hepatocellular carcinoma lenvatinib resistance colec12 nrg1 cancer stemness
Acesso em linha:	http://e-cmh.org/upload/pdf/cmh-2025-1059.pdf
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