Epigenetic mechanisms controlling human leukemia stem cells and therapy resistance

Abstract Cancer stem cells are essential for initiation and therapy resistance of many cancers, including acute myeloid leukemias (AML). Here, we apply functional genomic profiling to diverse human leukemias, including high-risk MLL- and NUP98-rearranged specimens, using label tracing in vivo. Human...

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Detalles Bibliográficos

Principais autores:	Sumiko Takao, Victor Morell, Masahiro Uni, Alicia Slavit, Sophia Rha, Shuyuan Cheng, Laura K. Schmalbrock, Fiona C. Brown, Sergi Beneyto-Calabuig, Richard P. Koche, Lars Velten, Alex Kentsis
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2025-04-01
Series:	Nature Communications
Acceso en liña:	https://doi.org/10.1038/s41467-025-58370-9
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