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Pharmacokinetics and Pharmacodynamics of a Nanostructured Lipid Carrier Co-Encapsulating Artemether and miRNA for Mitigating Cerebral Malaria

Cerebral malaria (CM), a severe neurological pathology caused by <i>Plasmodium falciparum</i> infection, poses a significant global health threat and has a high mortality rate. Conventional therapeutics cannot cross the blood–brain barrier (BBB) efficiently. Therefore, finding effective treatments r...

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Main Authors: Veera Venkata Nishanth Goli, Spandana Tatineni, Umme Hani, Mohammed Ghazwani, Sirajunisa Talath, Sathvik Belagodu Sridhar, Yahya Alhamhoom, Farhat Fatima, Riyaz Ali M. Osmani, Umamaheshwari Shivaswamy, Vichitra Chandrasekaran, Bannimath Gurupadayya
Format: Artigo
Language:Inglês
Published: MDPI AG 2024-04-01
Series:Pharmaceuticals
Subjects:
nanostructured lipid carrier
miRNA
pharmacokinetics
intranasal delivery
brain targeting
NOX2
Online Access:https://www.mdpi.com/1424-8247/17/4/466
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