Fully equipped CARs to address tumor heterogeneity, enhance safety, and improve the functionality of cellular immunotherapies

Although adoptive transfer of chimeric antigen receptor (CAR)-engineered T cells has achieved unprecedented response rates in patients with certain hematological malignancies, this therapeutic modality is still far from fulfilling its remarkable potential, especially in the context of solid cancers....

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Detalhes bibliográficos

Principais autores:	Antonio Maria Alviano, Marta Biondi, Erica Grassenis, Andrea Biondi, Marta Serafini, Sarah Tettamanti
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2024-06-01
coleção:	Frontiers in Immunology
Assuntos:	CAR-T cells adapter CARs (AdCARs) tandem CARs (TanCARs) logic-gated CARs safety switches epitope editing
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1407992/full
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