Benzothiazinone-piperazine derivatives as efficient Mycobacterium tuberculosis DNA gyrase inhibitors

Background and objectives: Bacterial DNA topoisomerases are unique in maintaining the DNA topology for cell viability. Mycobacterium tuberculosis (MTB) DNA gyrase, a sole type II topoisomerase has a larger scope as a target for developing novel therapeutics. In this study, an effort was made towards...

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Auteurs principaux:	Manoj Chandran, Janupally Renuka, Jonnalagadda Padma Sridevi, Ganesh S Pedgaonkar, Vanaparthi Asmitha, Perumal Yogeeswari, Dharmarajan Sriram
Format:	Artigo
Langue:	Inglês
Publié:	Wolters Kluwer Medknow Publications 2015-01-01
Collection:	International Journal of Mycobacteriology
Sujets:	Tuberculosis DNA gyrase Supercoiling Minimum inhibitory concentration
Accès en ligne:	http://www.ijmyco.org/article.asp?issn=2212-5531;year=2015;volume=4;issue=2;spage=104;epage=115;aulast=Chandran
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