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Benzothiazinone-piperazine derivatives as efficient Mycobacterium tuberculosis DNA gyrase inhibitors

Background and objectives: Bacterial DNA topoisomerases are unique in maintaining the DNA topology for cell viability. Mycobacterium tuberculosis (MTB) DNA gyrase, a sole type II topoisomerase has a larger scope as a target for developing novel therapeutics. In this study, an effort was made towards...

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Hauptverfasser: Manoj Chandran, Janupally Renuka, Jonnalagadda Padma Sridevi, Ganesh S Pedgaonkar, Vanaparthi Asmitha, Perumal Yogeeswari, Dharmarajan Sriram
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wolters Kluwer Medknow Publications 2015-01-01
Schriftenreihe:International Journal of Mycobacteriology
Schlagworte:
Tuberculosis
DNA gyrase
Supercoiling
Minimum inhibitory concentration
Online-Zugang:http://www.ijmyco.org/article.asp?issn=2212-5531;year=2015;volume=4;issue=2;spage=104;epage=115;aulast=Chandran
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