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Metabolic breakdown: Linking insulin resistance and mitochondrial dysfunction to neurodegeneration in Alzheimer’s disease

The increasing prevalence of metabolic disorders and neurodegenerative diseases has uncovered shared pathophysiological pathways, with insulin resistance and mitochondrial dysfunction emerging as critical contributors to cognitive decline. Insulin resistance impairs neuronal metabolism and synaptic...

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Principais autores: Simona Lanzillotta, Lucrezia Romana Rolfi, Barbara Zulli, Eugenio Barone
Format: Artigo
Sprog:Inglês
Udgivet: Wolters Kluwer Medknow Publications 2026-06-01
Serier:Neural Regeneration Research
Fag:
aging
alzheimer’s disease
brain insulin resistance
down syndrome
energy metabolism
glucagon-like peptide 1
incretins
insulin
mitochondria
neurodegeneration
Online adgang:https://journals.lww.com/10.4103/NRR.NRR-D-25-00144
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