Metabolic breakdown: Linking insulin resistance and mitochondrial dysfunction to neurodegeneration in Alzheimer’s disease

The increasing prevalence of metabolic disorders and neurodegenerative diseases has uncovered shared pathophysiological pathways, with insulin resistance and mitochondrial dysfunction emerging as critical contributors to cognitive decline. Insulin resistance impairs neuronal metabolism and synaptic...

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Detalhes bibliográficos

Principais autores:	Simona Lanzillotta, Lucrezia Romana Rolfi, Barbara Zulli, Eugenio Barone
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wolters Kluwer Medknow Publications 2026-06-01
coleção:	Neural Regeneration Research
Assuntos:	aging alzheimer’s disease brain insulin resistance down syndrome energy metabolism glucagon-like peptide 1 incretins insulin mitochondria neurodegeneration
Acesso em linha:	https://journals.lww.com/10.4103/NRR.NRR-D-25-00144
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