Beyond Genes: Inclusion of Alternative Splicing and Alternative Polyadenylation to Assess the Genetic Architecture of Predisposition to Voluntary Alcohol Consumption in Brain of the HXB/BXH Recombinant Inbred Rat Panel

Post transcriptional modifications of RNA are powerful mechanisms by which eukaryotes expand their genetic diversity. For instance, researchers estimate that most transcripts in humans undergo alternative splicing and alternative polyadenylation. These splicing events produce distinct RNA molecules,...

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Principais autores:	Ryan Lusk, Paula L. Hoffman, Spencer Mahaffey, Samuel Rosean, Harry Smith, Jan Silhavy, Michal Pravenec, Boris Tabakoff, Laura M. Saba
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2022-03-01
Serija:	Frontiers in Genetics
Teme:	HXB/BXH recombinant inbred panel voluntary alcohol consumption transcriptome weighted gene co expression network analysis alternative splicing alternative polyadenylation
Online dostop:	https://www.frontiersin.org/articles/10.3389/fgene.2022.821026/full
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