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Sirolimus treatment for intractable lymphatic anomalies: an open-label, single-arm, multicenter, prospective trial

IntroductionIntractable lymphatic anomalies (LAs) include cystic lymphatic malformation (LM; macrocystic, microcystic, or mixed), generalized lymphatic anomaly, and Gorham–Stout disease. LAs can present with severe symptoms and poor prognosis. Thus, prospective studies for treatments are warranted....

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Asıl Yazarlar: Michio Ozeki, Saori Endo, Shiho Yasue, Akifumi Nozawa, Ryuta Asada, Akiko M. Saito, Hiroya Hashimoto, Takumi Fujimura, Yohei Yamada, Tatsuo Kuroda, Shigeru Ueno, Shoji Watanabe, Shunsuke Nosaka, Mikiko Miyasaka, Akihiro Umezawa, Kentaro Matsuoka, Takanobu Maekawa, Satoshi Hirakawa, Taizo Furukawa, Shigehisa Fumino, Tatsuro Tajiri, Junkichi Takemoto, Ryota Souzaki, Yoshiaki Kinoshita, Akihiro Fujino
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2024-02-01
Seri Bilgileri:Frontiers in Medicine
Konular:
lymphatic anomalies
lymphatic malformation
generalized lymphatic anomaly
Gorham–stout disease
mammalian target of rapamycin
Online Erişim:https://www.frontiersin.org/articles/10.3389/fmed.2024.1335469/full
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