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Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes osteoclast differentiation

Abstract Bone resorption is driven through osteoclast differentiation by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor kappa-Β ligand (RANKL). We noted that a disintegrin and metalloproteinase (ADAM) 10 and ADAM17 are downregulated at the expression level duri...

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Principais autores: Aaron Babendreyer, Julia Kieselhorst, Cindy Rinkens, Anastasia M. Lyashenko, Stefan Düsterhöft, Holger Jahr, Rogerio B. Craveiro, Michael Wolf, Andreas Ludwig
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-06-01
coleção:Cell Communication and Signaling
Assuntos:
Osteoclast
Monocyte
Metalloproteinase
Shedding
Colony stimulating factor 1 receptor
Receptor activator of nuclear factor kappa-Β ligand
Acesso em linha:https://doi.org/10.1186/s12964-024-01690-y
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